The resulting failure of infected immune cells to clear bacteria, in combination with their highly migratory and tissue-invasive properties, can lead to a spread of the surviving bacteria and result in systemic and chronic infections 2, 7, 8, 9. Although immune cells have optimized their ability to recognize and kill bacteria, some pathogenic bacteria specifically target cells of the immune system and achieve intracellular survival. ![]() via release of proteins that enter host cells and promote bacterial internalization 5, 6. when immune cells recognize and actively phagocytose infecting bacteria, or by the bacteria, e.g. ![]() The internalization of bacteria into eukaryotic host cells can be triggered either by the host cells, e.g. While internalization of microbes by immune cells often leads to their intracellular degradation, survival within host cells is a potent mechanism of bacterial virulence and antibiotic evasion 1, 2, 3, 4.
0 Comments
Leave a Reply. |