![]() Our key observation is that the incorporation signals of neighboring flows, even after normalization and phase correction, carry considerable mutual information and are important in making the correct base-call. ![]() Results: We present FlowgramFixer, a new algorithm for converting flowgrams into reads. Despite the advantages, however, Ion Torrent read accuracy remains a significant concern. Because of its exploitation of ubiquitous semiconductor technology and innovation in chemistry, Ion Torrent has been gaining popularity since its debut in 2011. A major player is Ion Torrent, a pyrosequencing-like technology which produces flowgrams – sequences of incorporation values – which are converted into nucleotide sequences by a base-calling algorithm. Motivation: The importance of fast and affordable DNA sequencing methods for current day life sciences, medicine and biotechnology is hard to overstate.
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